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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 12, Number 1, 2018

Articles

Free Content Graphical Abstracts
pp. i-v(5)

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Free Content Meet Our Editorial Board Member
pp. 1-1(1)
Author: Sinz, Michael

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Preface

Free Content Preface
pp. 2-2(1)
Author: Balani, Suresh

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Research article

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions
pp. 3-13(11)
Authors: Wong, Susan; Doshi, Utkarsh; Vuong, Peter; Liu, Ning; Tay, Suzanne; Le, Hoa; Kosaka, Mika; Kenny, Jane R.; Li, Albert P.; Yan, Zhengyin

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Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells
pp. 14-23(10)
Authors: Ogasawara, Akira; Kato, Nozomu; Torimoto, Nao; Aohara, Fumika; Ohashi, Rikiya; Yamada, Yasuhiro; Taniguchi, Hideki

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LC-MS/MS Identification and Structural Characterization of Main Biodegradation Products of Nitroproston - A Novel Prostaglandin-based Pharmaceutical Compound
pp. 54-61(8)
Authors: Mesonzhnik, Natalia V.; Moskaleva, Natalia E.; Shestakova, Ksenia M.; Kurynina, Ksenya O.; Baranov, Pavel A.; Gretskaya, Natalia M.; Serkov, Igor V.; Lyubimov, Igor I.; Bezuglov, Vladimir V.; Appolonova, Svetlana A.

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Evaluation of Herb-Drug Interaction of Synacinn™ and Individual Biomarker through Cytochrome 450 Inhibition Assay
pp. 62-67(6)
Authors: Ab Rahman, Nur S.; Abd Majid, Fadzilah Adibah; Abd Wahid, Mohd Effendy; Zainudin, Ain Nabihah; Zainol, Siti Nurazwa; Ismail, Hassan Fahmi; Wong, Tet Soon; Tiwari, Nirbhay Kumar; Giri, Sanjeev; Bhargava, Vijaya

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Effect of CYP2D6 Poor Metabolizer Phenotype on Stereoselective Nebivolol Pharmacokinetics
pp. 68-70(3)
Authors: Vieira, Carolina P.; Neves, Daniel V.; Coelho, Eduardo B.; Lanchote, Vera L.

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Case report

Articles

Open Access Evaluation of the Effect of Uremic Serum on Hepatic Reductase Functional Expression
pp. 75-81(7)
Authors: Alshogran, Osama Y.; Al-Obaidi, Esra'a F.; Al-Husein, Belal A.; Oweis, Ashraf O.

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