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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 10, Number 2, 2016

Articles

Free Content Graphical Abstracts:
pp. i-iii(3)

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Free Content Meet Our Editorial Board Member:
pp. 71-71(1)
Author: Ulgen, Mert

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The Effects of Statin Therapy on the Human Airway
pp. 75-82(8)
Authors: Thong, Lorraine; MacSharry, John; M. Murphy, Desmond

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Free Content Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability
pp. 83-90(8)
Authors: J. Richardson, Samantha; Bai, April; A. Kulkarni, Ashutosh; F. Moghaddam, Mehran

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Free Content Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat
pp. 91-100(10)
Authors: W. Fan, Peter; Z. Chen, Jacob; Allan Jaochico, M.; La, Hank; Liu, Ning; Mulder, Teresa; T. Cass, Robert; Durk, Matthew; Messick, Kirsten; Valle, Nicole; Liu, Shannon; Lee, Wendy; J. Crawford, James; Rudolf, Joachim; J. Murray, Lesley; Cyrus Khojasteh, S.; Wright, Matthew

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In Vitro Study of UGT Metabolism and Permeability of Orientin and Isoorientin, Two Active flavonoid C-glycosides
pp. 101-110(10)
Authors: Shi, Jian; Zhu, Lijun; Li, Ye; Zheng, Haihui; Yu, Jia; Lu, Linlin; Liu, Zhongqiu

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Biotransformation of Cobicistat: Metabolic Pathways and Enzymes
pp. 111-123(13)
Authors: Wang, Pengcheng; I. Shehu, Amina; Liu, Ke; Lu, Jie; Ma, Xiaochao

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In Vitro CYP2D Inhibitory Effect and Influence on Pharmacokinetics and Pharmacodynamic Parameters of Metoprolol Succinate by Terminalia arjuna in Rats
pp. 124-135(12)
Authors: Varghese, Alice; Savai, Jay; Mistry, Shruti; Khandare, Preeti; Barve, Kalyani; Pandita, Nancy; Gaud, Ram

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Elucidating the Mechanism of Tofacitinib Oxidative Decyanation
pp. 136-143(8)
Authors: Le, Hoa; W. Fan, Peter; Wong, Susan; Ma, Shuguang; P. Driscoll, James; E.C.A. Hop, Cornelis; Cyrus Khojasteh, S.

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Free Content Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation
pp. 144-150(7)
Authors: L. Apuy, Julius; Xiang, Cathie; Franc, Sarah; G. Hegde, Sayee; Hubbard, Robert; Zhao, Jingjing; F. Moghaddam, Mehran

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