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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 6, Number 4, 2012

Articles

Open Access Formation/Fate of Reactive Metabolites from General Anesthetics and A Comparison of Toxic and Non-Toxic Analogues: A DFT Study
pp. 221-234(14)
Authors: Bhatia, Sonam; A. Dixit, Vaibhav; Jangra, Harish; V. Bharatam, Prasad

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Open Access Pharmacokinetic Profile of A New Diclofenac Prodrug without Gastroulcerogenic Effect
pp. 235-241(7)
Authors: Leandro de Campos, Michel; Mariana Baldan-Cimatti, Helen; Gomes Davanco, Marcelo; Antonio Ferraz Nogueira, Marco; Carvalho Padilha, Elias; Damico Candido, Caroline; Leandro dos Santos, Jean; Goncalves Peccinini, Rosangela

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Open Access Renal and Hepatic Kinetics of Tc-99m-labelled Hexakis-methoxy-isobutyl Isonitrile
pp. 242-246(5)
Authors: Dizdarevic, Sabina; Aplin, Mark; Ryan, Nicola; G. Holt, Stephen; Goldberg, Lawrence; A. Miles, Kenneth; Michael Peters, A.

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Open Access The Evaluation of CYP2B6 Inhibition by Artemisinin Antimalarials in Recombinant Enzymes and Human Liver Microsomes
pp. 247-257(11)
Authors: Ericsson, Therese; Masimirembwa, Collen; Abelo, Angela; Ashton, Michael

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Open Access Application of 1D and 2D 1H-NMR in the Structural Elucidation of a N-Glucuronidated Metabolite and Oxidized Metabolites Generated in Microsomal Incubation
pp. 265-274(10)
Authors: L. Apuy, Julius; Bai, April; Paisner, David; G. Hegde, Sayee; F. Moghaddam, Mehran

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Open Access Development of Flavone Propargyl Ethers as Potent and Selective Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2
pp. 275-284(10)
Authors: Sridhar, Jayalakshmi; Ellis, Jamie; Dupart, Patrick; Liu, Jiawang; L. Stevens, Cheryl; Foroozesh, Maryam

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Open Access A Transcellular Assay to Assess the P-gp Inhibition in Early Stage of Drug Development
pp. 285-291(7)
Authors: Taur, Jan-Shiang; L. Schuck, Edgar; Y. Wong, Nancy

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