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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 6, Number 1, 2012

Articles

Open Access PREFACE
pp. 1-1(1)
Author: Prakash, Chandra

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Open Access Changes of Drug Metabolizing Enzymes in the Liver of Male Sheep Exposed to either Cypermethrin or Dimethoate
pp. 2-6(5)
Authors: A. Sheweita, S.; I. Yousef, M.; H. Baghdadi, H.; G. Elshemy, A.

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Open Access Molecular Analysis and Modeling of Inactivation of Human CYP2D6 by Four Mechanism Based Inactivators
pp. 7-14(8)
Authors: Livezey, Mara; D. Nagy, Leslie; E. Diffenderfer, Laura; J. Arthur, Evan; J. Hsi, David; M. Holton, Jeffrey; Lowe Furge, Laura

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Open Access Comparative Analysis of In Vitro Rat Liver Metabolism of the Antimalarial Primaquine and a Derived Imidazoquine
pp. 15-25(11)
Authors: Vale, Nuno; Fernandes, Iva; Moreira, Rui; Mateus, Nuno; Gomes, Paula

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Open Access Loxapine P-glycoprotein Interactions In Vitro
pp. 26-32(7)
Authors: Reed, Andrea; Huie, Keith; S. Perloff, Elke; V. Cassella, James; H. Takahashi, Lori

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Open Access Preclinical Metabolism and Pharmacokinetics of SB1317 (TG02), a Potent CDK/JAK2/FLT3 Inhibitor
pp. 33-42(10)
Authors: Khalid Pasha, Mohammed; Jayaraman, Ramesh; Pilla Reddy, Venkatesh; Yeo, Pauline; Goh, Evelyn; Williams, Anthony; Chuan Goh, Kee; Kantharaj, Ethirajulu

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Open Access Evaluation of Time-Dependent Cytochrome P450 Inhibition in a High-Throughput, Automated Assay: Introducing a Novel Area Under the Curve Shift Approach
pp. 43-53(11)
Authors: Mukadam, Sophie; Tay, Suzanne; Tran, Daniel; Wang, Leslie; M. Delarosa, Erlie; Cyrus Khojasteh, S.; S. Halladay, Jason; R. Kenny, Jane

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Open Access New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger
pp. 54-59(6)
Authors: Malanga, Gabriela; Belen Aguiar, Maria; D. Martinez, Hugo; Puntarulo, Susana

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