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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 4, Number 4, 2010

Articles

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P-Glycoprotein, but not Multidrug Resistance Protein 4, Plays a Role in the Systemic Clearance of Irinotecan and SN-38 in Mice
pp. 195-201(7)
Authors: Tagen, Michael; Zhuang, Yanli; Zhang, Fan; Elaine Harstead, K.; Shen, Jun; Schaiquevich, Paula; H. Fraga, Charles; C. Panetta, John; M. Waters, Christopher; F. Stewart, Clinton

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P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase Inhibitor
pp. 202-212(11)
Authors: J. Yang, Johnny; N. Milton, Mark; Yu, Shaoxia; Liao, Mingxiang; Liu, Ning; Wu, Jing-Tao; Gan, Liang-Shang; K. Balani, Suresh; W. Lee, Frank; Prakash, Shimoga; Q. Xia, Cindy

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Contribution of Three CYP3A Isoforms to Metabolism of R- and S-Warfarin
pp. 213-219(7)
Authors: R. Jones, Drew; Kim, So-Young; Boysen, Gunnar; Yun, Chul-Ho; P. Miller, Grover

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Reversible Covalent Binding of Neratinib to Human Serum Albumin In Vitro
pp. 220-227(8)
Authors: Chandrasekaran, Appavu; Shen, Li; Lockhead, Susan; Oganesian, Aram; Wang, Jianyao; Scatina, JoAnn

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Daunorubicin Metabolism in Leukemic Cells Isolated from Patients with Acute Myeloid Leukemia
pp. 228-232(5)
Authors: Bogason, Alex; Masquelier, Michele; Lafolie, Pierre; Skogastierna, Cristine; Paul, Christer; Gruber, Astrid; Vitols, Sigurd

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In Vitro Screening of Metabolic Clearance Using Two Concentration Points
pp. 233-240(8)
Authors: T. Williams, Eric; Farah, Nadia; D. Pelletier, Robert; George Lai, W.

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Comparative Efflux of Saquinavir, Ritonavir and Lopinavir from Primary Human Cells
pp. 241-245(5)
Authors: Diker, Bilge; Janneh, Omar; P.G. van Heeswijk, Rolf; F.T. Copeland, Karen

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Co-Expression of Recombinant Human CYP2C9 with Human Cytochrome P450 Reductase in Protease Deficient S. cerevisiae Strain at a Higher Scale Yields an Enzyme of Higher Specific Activity
pp. 246-253(8)
Authors: N. Purnachandra Rao, K.; Kumar Suman, Sunil; Ravi Kiran, Y.; Ranjan Kuanr, Arup; Kumar Gupta, Anuj; Bhalla, Kunal; Kumar, Vipul; Kundu, Prabuddha; Arora, Kajal; Soni, Rajeev

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Two Branched Polar Groups and Polar Linker Moieties of Thiophene Amide Derivatives Are Essential for MRP2/ABCC2 Recognition
pp. 254-261(8)
Authors: Hu, Yiding; E. Sampson, Kathleen; Xing, Li; Li, Na; R. Heyde, Bruce; Xie, Jin; Lai, Yurong

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