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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 3, Number 1, 2009

Articles

Molecular Analysis of the In Vivo Metabolism and Biodistribution of Metabolically and Non-Metabolically Activated Combi-Molecules of the Triazene Class
pp. 1-9(9)
Authors: Qiu, Qiyu; Larroque, Anne-Laure; Gibbs, Bernard; Fang, Youqiang; Lakhrissi, Younes; Soucy, Jean-Paul; Mzengeza, Shadreck; Rachid, Zakaria; Jean-Claude, Bertrand J.

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O-Demethylation of Dextromethorphan Using Microbial Cultures
pp. 10-14(5)
Authors: Prasanthi, Samathoti; Vidyavathi, Maravajhala; Prasad, Koganti V.S.R.G.; Krishna, Devarakonda R.

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Impact of Cerebral Malaria on Brain Distribution of Mefloquine
pp. 15-17(3)
Authors: de Lagerie, Sylvie B.; Fernandez, Christine; German-Fattal, Michele; Gantier, Jean-Charles; Gimenez, Francois; Farinotti, Robert

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Structure-Activity Relationship (SAR): Effort Towards Blocking NGlucuronidation of Indazoles (PF-03376056) By Human UGT1A Enzymes
pp. 28-34(7)
Authors: Rose, Kelly; Yang, Young-Sun; Sciotti, Richard; Cai, Hongliang

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Copper (II) Complexes of [1,2,4]Triazolo [1,5-a]Pyrimidine Derivatives as Potential Anti-Parasitic Agents
pp. 35-44(10)
Authors: Boutaleb-Charki, Samira; Marin, Clotilde; Maldonado, Carmen R.; Rosales, Maria J.; Urbano, Jesus; Guitierrez-Sanchez, Ramon; Quiros, Miguel; Salas, Juan M.; Sanchez-Moreno, Manuel

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Impact of Time-Dependent Inactivation on the Estimation of Enzyme Kinetic Parameters for Midazolam
pp. 45-53(9)
Authors: Giragossian, Craig; LaPerle, Jennifer; Kosa, Rachel E.; Gillian, Sarah

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Inhibitory Effect of Codeine on Sucrase Activity
pp. 58-60(3)
Authors: Minai-Tehrani, Dariush; Minoui, Saeed; Sepehre, Marzie; Sharif-Khodai, Zohre; Aavani, Tooka

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Co-Induction of CYP3A12 and 3A26 in Dog Liver Slices by Xenobiotics: Species Difference Between Human and Dog CYP3A Induction
pp. 61-66(6)
Authors: Chen, Jun; Tran, Cindy; Xiao, Li; Palamanda, Jairam; Klapmuts, Thomas; Kumari, Pramila; Lin, Xinjie; Wang, Er-jia; Gu, Yi-Zhong; Humphries, Mary; Uss, Annette S.; Cheng, K.-C.

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