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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 2, Number 4, 2008

Articles

Induction of Human UGT1A1 by Bilirubin Through AhR Dependent Pathway
pp. 231-237(7)
Authors: Togawa, Hiroshi; Shinkai, Shigeko; Mizutani, Takaharu

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Study of Oxidized Lipids as Endogenous Substrates of P-gp (ABCB1)
pp. 238-244(7)
Authors: Masuda, Masatoshi; Nakai, Emi; Mizutani, Takaharu

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Effect of the Acute Phase Response Induced by Endotoxin Administration on the Expression and Activity of UGT Isoforms in Rats
pp. 248-255(8)
Authors: Alkharfy, Khalid M.; Poloyac, Samuel M.; Congiu, Mario; Desmond, Paul V.; Frye, Reginald F.

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Pharmacokinetic and Pharmacodynamic Predictions of Novel Potential HIV-1 Integrase Inhibitors
pp. 256-260(5)
Authors: da Silva, C.H. T.P.; da Silva, V.B.; Taft, C. A.

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Identification of Four Urea Adducts of Andrographolide in Humans
pp. 261-268(8)
Authors: Cui, Liang; Chan, Wan; Qiu, Feng; Cai, Zongwei; Yao, Xinsheng

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Increase of R-/S-Methadone Enantiomer Concentration Ratio in Serum of Patients Treated with Either Nevirapine or Efavirenz
pp. 269-274(6)
Authors: Esteban, Javier; Cruz Pellin, Maria d. l.; Gimeno, Carmen; Barril, Jose; Gimenez, Jesus; Mora, Eva; Garcia-Perez, Adolfo G.

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Synthesis of Haloperidol Prodrugs and Their Hydrolysis by Porcine Liver Esterase
pp. 275-279(5)
Authors: Morris, Andrew P.; Brain, Keith R.; Heard, Charles M.

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Decreased Valproate Level Caused by VPA-glucuronidase Inhibition by Carbapenem Antibiotics
pp. 280-285(6)
Authors: Nakamura, Yutaka; Nakahira, Keiko; Mizutani, Takaharu

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Covariates of Amikacin Clearance in Neonates: The Impact of Postnatal Age on Predictability
pp. 286-289(4)
Authors: Allegaert, Karel; Scheers, Isabelle; Cossey, Veerle; Anderson, Brian J.

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Free Content Heme Oxygenase-Derived Carbon Monoxide Restores Vascular Function in Type 1 Diabetes
pp. 290-300(11)
Authors: Rodella, Luigi F.; Vanella, Luca; Peterson, Stephen J.; Drummond, George; Rezzani, Rita; Falck, John R.; Abraham, Nader G.

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In Vitro Metabolism Studies of New Adenosine A
pp. 301-307(7)
Authors: Marucci, Gabriella; Finaurini, Sara; Buccioni, Michela; Lammi, Carmen; Kandhavelu, Meenakshisundaram; Volpini, Rosaria; Ricciutelli, Massimo; Angeli, Piero; Commandeur, Jan N.M.; Cristalli, Gloria

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