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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 2, Number 2, 2008

Articles

Free Content Influence of ABCB1 Gene Polymorphisms and P-Glycoprotein Activity on Cyclosporine Pharmacokinetics in Peripheral Blood Mononuclear Cells in Healthy Volunteers
pp. 76-82(7)
Authors: Ansermot, Nicolas; Rebsamen, Michela; Chabert, Jocelyne; Fathi, Marc; Gex-Fabry, Marianne; Daali, Youssef; Besson, Marie; Rossier, Michel; Rudaz, Serge; Hochstrasser, Denis; Dayer, Pierre; Desmeules, Jules

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Brain-to-Plasma Distribution Ratio of the Biflavone Amentoflavone in the Mouse
pp. 90-94(5)
Authors: Colovic, Milena; Fracasso, Claudia; Caccia, Silvio

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Analysis of Flavin-Containing Monooxygenase 3 Genotype Data in Populations Administered the Anti-Schizophrenia Agent Olanzapine
pp. 100-114(15)
Authors: Cashman, John R.; Zhang, Jun; Nelson, Matthew R.; Braun, Andreas

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Effect of Folic Acid on Methotrexate Induction of Sulfotransferases in Rats
pp. 115-119(5)
Authors: Dutta, Sangita M.; Maiti, Smarajit; Chen, Guangping

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The Use of 1-Aminobenzotriazole in Differentiating the Role of CYPMediated First Pass Metabolism and Absorption in Limiting Drug Oral Bioavailability: A Case Study
pp. 120-124(5)
Authors: El-Kattan, Ayman F.; Poe, Julie; Buchholz, Lisa; Thomas, Hayden V.; Brodfuehrer, Joanne; Clark, Alan

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Stability of Methadone and Its Main Metabolite in Oral Fluid
pp. 125-129(5)
Authors: Fucci, Nadia; Giovanni, Nadia D.

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Quantitative Structure-Retention-Pharmacokinetic Relationship Studies
pp. 130-137(8)
Authors: Agatonovic-Kustrin, Snezana; Turner, Joseph V.; Glass, Beverley D.

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Free Content Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats
pp. 138-145(8)
Authors: Wergedahl, Hege; Berge, Kjetil; Bohov, Pavol; Tronstad, Karl-Johan; Madsen, Lise; Berge, Rolf K.

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Pharmacokinetics and Metabolism of Diltiazem Following Multiple Doses:Comparing Normotensive Rat vs. Hypertensive Rat Models In vivo
pp. 146-150(5)
Authors: Yeung, Pollen K.F.; Alcos, Angelita; Tang, Jinglan; Casley, William l.

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