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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 1, Number 3, 2007

Articles

Antioxidants Suppress Th1-Type Immune Response In Vitro
pp. 166-171(6)
Authors: Katharina Schroecksnadel; Birgit Fischer; Harald Schennach; Guenter Weiss; Dietmar Fuchs

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Effect of Neurotransmitters on NADPH-Cytochrome P450 Reductase In Vitro Activity
pp. 172-175(4)
Authors: Guillermo Gervasini; Carmen Martinez; Julio Benitez; Jose A.G. Agundez

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cAMP-Mediated Regulation of CYP Enzymes and Its Application in Chemotherapy
pp. 176-178(3)
Authors: Yoshihiro Ishikawa; Sayaka Suzuki; Koji Otsu; Coskun Ulucan; Kousaku Iwatsubo; Haruki Eguchi

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PET-Evaluated Transport of [11C]Hydroxyurea Across the Rat Blood-Brain Barrier - Lack of Influence of Cyclosporin and Probenecid
pp. 189-194(6)
Authors: Stina Syvanen; Julien Barletta; Gunnar Blomquist; Bengt Langstrom; Mats Bergstrom

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An Indirect Screen for Brain Uptake of 1,2-Diarylethane Melanocortin 4 Receptor Antagonists in Rats
pp. 195-198(4)
Authors: Wei Yin; Liang-Shang Gan; Jing-Tao Wu; Suresh K. Balani; Hua Yang; Frank W. Lee

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Effects of Various Promoter Derived Sequences on the Cleavage Kinetic of an Hammerhead Ribozyme Directed Against Cyclin E1 mRNA
pp. 218-225(8)
Authors: Johannes Platz; Mario Grassi; Anne Kuhn; Reinhard Kandolf; Giorgia Racchi; Rossella Farra; Barbara Dapas; Andrea Pascotto; Carlo Giansante; Nicola Fiotti; Gianfranco Guarnieri; Gabriele Grassi

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Application of Liquid Chromatography-Accelerator Mass Spectrometry (LC-AMS) to Evaluate the Metabolic Profiles of a Drug Candidate in Human Urine and Plasma
pp. 226-231(6)
Authors: Chandra Prakash; Christopher L. Shaffer; Larry M. Tremaine; Rosa G. Liberman; Paul L. Skipper; Jimmy Flarakos; Steven R. Tannenbaum

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Studies of Bioactivity, Conformation and Pharmacokinetic Profiles of Site-Specific PEGylated Thymosin Alpha 1 Derivatives
pp. 232-340(109)
Authors: Jiankun Qie; Jinbo Ma; Liangyou Wang; Xiaoyu Xu; Jianquan Zheng; Sijian Dong; Jianwei Xie; Huixian Sun; Wenxia Zhou; Chunhui Qi; Xiunan Zhao; Yongxiang Zhang; Keliang Liu

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