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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 1, Number 2, 2007

Articles

An Estimate of the Number of Hepatocyte Donors Required to Provide Reasonable Estimates of Human Hepatic Clearance from In Vitro Experiments
pp. 91-95(5)
Authors: Byers, James; Bachmann, Kenneth; Eng, Heather; Katta, Anand; White, Donald; Ghosh, Ritwik; Hewitt, Nicola J.; Silber, Paul; Chen, Genfu

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A Glucuronidation Pathway of Capecitabine Occurs in Rats but Not in Mice and Humans
pp. 101-107(7)
Authors: Desmoulin, F.; Claparols, C.; Bon, D.; Larrieu, G.; Martino, R.; Malet-Martino, M.

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The Human Sperm Glutathione System: A Key Role in Male Fertility and Successful Cryopreservation
pp. 121-126(6)
Authors: Meseguer, Marcos; Antonio Martinez-Conejero, Jose; Muriel, Lourdes; Pellicer, Antonio; Remohi, Jose; Garrido, Nicolas

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Application of Simple Mathematical Expressions to Relate Half-Lives of Drugs in Mice to Those in Humans
pp. 127-129(3)
Authors: Bachmann, Kenneth; Chupka, Jonathan; Erhardt, Paul; White, Donald

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Intracellular Delivery of Nanogel-Quantum Dot Hybrid Nanoparticles into Human Periodontal Ligament Cells
pp. 131-135(5)
Authors: Fukui, Tomoe; Kobayashi, Hiroaki; Hasegawa, Urara; Nagasawa, Toshiyuki; Akiyoshi, Kazunari; Ishikawa, Isao

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Resin-Salve from Norway Spruce - A Potential Method to Treat Infected Chronic Skin Ulcers?
pp. 143-145(3)
Authors: Sipponen, Arno; Rautio, Merja; Jokinen, Janne J.; Laakso, Tapio; Saranpaa, Pekka; Lohi, Jouni

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The Utility of Stable Cell Lines to Assess Species Differences in PXR Transactivation
pp. 147-152(6)
Authors: Sinz, Michael W.; Pray, Devin; Raucy, Judy

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Disposition of Vorinostat, A Novel Histone Deacetylase Inhibitor and Anticancer Agent, in Preclinical Species
pp. 153-161(9)
Authors: Sandhu, Punam; Andrews, Paul A.; Baker, Maribeth P.; Koeplinger, Kenneth A.; Soli, Eric D.; Miller, Thomas; Baillie, Thomas A.

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Frequency of CYP1A2 Polymorphism in Beagle Dogs
pp. 163-165(3)
Authors: Whiterock, Valerie J.; Delmonte, Terrye A.; Hui, Lester E.; Orcutt, Tami L.; Sinz, Michael W.

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