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Drug Metabolism Letters publishes short papers on major advances in all areas of drug metabolism and disposition. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of the Internet technology for both the submission and review of manuscripts. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Publisher: Bentham Science Publishers

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Volume 1, Number 1, 2007

Articles

EDITORIAL
pp. 1-1(1)
Author: Prakash, Chandra

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Effect of Common NAT2 Variant Alleles in the Acetylation of the Major Clonazepam Metabolite, 7-minoclonazepam
pp. 3-5(3)
Authors: Olivera, M.; Martinez, C.; Gervasini, G.; Carrillo, J. A.; Carrillo, J. A.; Ramos, S.; Benitez, J.; Garcia-Martin, E.; G. Agundez, J. A.

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Verapamil, but not Probenecid, Co-Administration Can Convert Desloratadine to a Sedating Antihistamine in Mice
pp. 7-11(5)
Authors: Katta, Anand; Dhananjeyan, Mugunthu; Bykowski, Crystal; Erhardt, Paul; Hacker, Miles; White, Donald B.; Bachmann, Kenneth

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Comparison of Paraben Stability in Human and Rat Skin
pp. 17-21(5)
Authors: Harville, Heather M.; Voorman, Richard; Prusakiewicz, Jeffery J.

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ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan
pp. 23-30(8)
Authors: Rhodes, Katrin E.; Zhang, Wu; Yang, Dongyun; Press, Oliver A.; Gordon, Michael; Vallbohmer, Daniel; Schultheis, Anne M.; Lurje, Georg; Ladner, Robert D.; Fazzone, William; Lenz, Heinz-Josef; Iqbal, Syma

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Drug Confinement and Delivery in Ceramic Implants
pp. 37-40(4)
Authors: Vallet-Regi, Maria; Balas, Francisco; Colilla, Montserrat; Manzano, Miguel

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Application of Pharmacogenomics in Drug Discovery and Development:Correlations Between Transcriptional Modulation and Preclinical Safety Observations
pp. 41-48(8)
Authors: Yengi, Lilian G.; Xiang, Qian; Shen, Li; Chandrasekaran, Appavu; Kao, John; Scatina, JoAnn

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A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis
pp. 49-53(5)
Authors: Abe, Akira; Hiraoka, Miki; Shayman, James A.

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A Unique Example of Drug Metabolism: Tetra- and Penta-Oxygenation Reactions of Capravirine in Rats, Dogs and Humans
pp. 61-65(5)
Authors: Bu, Hai-Zhi; Pool, William F.; Wu, Ellen Y.; Shetty, Bhasker V.

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Metabolic Stability Screen for Drug Discovery Using Cassette Analysis and Column Switching
pp. 67-72(6)
Authors: Halladay, Jason S.; Wong, Susan; Jaffer, Sharmin M.; Sinhababu, Achintya K.; Cyrus Khojasteh-Bakht, S.

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Structures of Various Cytochromes c Evaluated from the Redox Behaviors Using the Optically Active Co(III) Complex-Modified Au Electrode
pp. 73-75(3)
Authors: Takahashi, Isao; Nishijima, Chika; Inomata, Tomohiko; Funahashi, Yasuhiro; Ozawa, Tomohiro; Masuda, Hideki

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Effects of Propofol Analogs on Glucuronidation of Propofol, an Anesthetic Drug, by Human Liver Microsomes
pp. 77-79(3)
Authors: Shimizu, Makiko; Matsumoto, Yoshiaki; Yamazaki, Hiroshi

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Drug Interactions of Tipranavir, a New HIV Protease Inhibitor
pp. 81-84(4)
Authors: Morello, Judit; Rodriguez-Novoa, Sonia; Jimenez-Nacher, Inmaculada; Soriano, Vincent

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