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Role of Microspheres in Drug Delivery-An Overview

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From the last two decades, pharmaceutical scientists are developing the microspheres, free flowing powdered advanced drug delivery systems, not only as carrier systems to deliver different drugs at the controlled rate, but also to gain the therapeutic benefit to treat different diseases like cancer and growth disorders and also for radiological applications. Pharmaceutically, microspheres are solids; approximately spherical particles ranging in size from 1-1000 ┬Ám. They are made up of polymeric substances, in which the drug is dispersed throughout the microspheres matrix. Microspheres, due to high surface area and low particle size significantly increase the absorption rate and bio-availability. They are also useful to provide the controlled release or sustained release and site specific drug delivery. In future by combining various other strategies microsphere will find a central place in advanced drug delivery, particularly in diagnostics, diseased cell sorting, gene and genetic material delivery, targeted and effective in-vivo delivery. The present review explains the methodology of preparation of microspheres, method of evaluation and their recent applications and also updates the recent research on microspheres.
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Keywords: Controlled release; advanced drug delivery; microspheres; spherical particles; therapeutic efficacy

Document Type: Research Article

Publication date: December 1, 2013

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  • Drug Delivery Letters publishes short papers in all important aspects of drug delivery, gene delivery, and drug targeting. Short papers report seminal results and research approaching conclusion of importance in the field.

    The journal scope covers all basic and applied research in drug delivery and targeting at molecular and cellular levels and novel delivery systems. The manuscript submission process is fully electronic , to ensure the rapid publication of research results.

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