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Recent Patents and Trends in Orally Disintegrating Tablets

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Orally disintegrating tablets (ODTs) offer many advantages over the conventional oral dosage forms in terms of convenience and ease of use. Over the last decade, substantial advances in the formulation of ODTs have been achieved in academia and industry that resulted in the emerging of a large number of patents. The aim of this review is to summarise the most recent patents in ODT formulations and highlight their motivations, inventive steps and significances in the development of ODT formulations. Five major techniques have been applied in manufacturing of ODTs, namely conventional tablet press, moulding, freeze drying, tablet loading and pulverization, with majority of the patents dedicated to the use of conventional tablet pressing. The patents have addressed various issues concerning the manufacturing of robust and practical ODT formulations by disclosing new manufacturing techniques, advantageous materials, and innovative formulation steps. However, future developments are required to reduce the cost and widening the application of the new manufacturing techniques, while simplifying and shortening the formulation steps will be crucial in the well established ones.

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Keywords: Acetaminophen; Antibiotics; Conventional Tablet Press; Corn starch; D-mannitol; Domperidone; Flow agent; Galanthamine hydrobromide; Glidants; Ibuprofen; Lansoprazole; Lower critical solution temperature; Manufacturing; Meloxicam; Melt-granulation; Micronised; Mitiglinide Calcium hydrate; N-acetylglucosamine; Neutral core; Ondansetron; Orally disintegrating tablets; Oxycodone; Parkinson's disease; Ranitidine salt; Saccharrides; Sieving; Spray drying; Starch clays (kaolin); Surfactant; Titanium dioxide; Valdecoxib; acacia; acetaminophen; agar; agglomerates; agglomeration; amoxicillin; anhydrous silicic acid; antiemetic activity; aspartame; aspirin; azeotropic mixtures; bioavailability; compression; corn starch synergises; cosmetic; croscarmellose cellulose); crospovidone; cushioning components; diluents; disintegration mechanism; dysphagia; effervescent acid (malic acid); erythritol; ethanol; excipient; flavouring agents; fluoroalkanes; fracturability; freeze drying; gastrokinetic; geriatric patients; glidants; granulation-compression; guar; humectant; hydroxypropyl- cellulose; ketoprofen; lansoprazole; lubricant; lubricants; magnesium hydroxide; matrix forming agents; methacrylic acid copolymers; microcrystalline cellulose; mouldability; moulding; nifidipine; no-vacuum lyophilisation; nutraceutical; oxycodone; pellets; permeabilizing agents; polymethacrylate; polyvinyl alcohol; polyvinylpyrrolidone; prophylaxis; pulverization; salivating agents; sclerosis; silicified microcrystalline; silicified microcrystalline cellulose; starch; steroidal anti-inflammatory drugs; stevia; temazepam; thermo-labile; water-soluble excipients; wicking effect; xanthan gum

Document Type: Research Article

Publication date: November 1, 2010

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  • Recent Patents on Drug Delivery and Formulation publishes review articles by experts on recent patents on drug delivery and formulation. A selection of important and recent patents on drug delivery and formulation is also included in the journal. The journal is essential reading for all researchers involved in the fields of drug delivery and formulation.
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