Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Bruner-Tran, Kaylon L.
AU - Mokshagundam, Shilpa
AU - Herington, Jennifer L.
AU - Ding, Tianbing
AU - Osteen, Kevin G.
TI - Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets
JO - Current Women's Health Reviews
PY - 2018-06-01T00:00:00///
VL - 14
IS - 2
SP - 173
EP - 188
KW - epigenetics
KW - rat
KW - mice
KW - inflammation
KW - co-morbidities
KW - steroid action
KW - Endometriosis
N2 - Background: Although it has been more than a century since endometriosis was initially described in the literature, understanding the etiology and natural history of the disease has been challenging. However, the broad utility of murine and rat models of experimental endometriosis has
enabled the elucidation of a number of potentially targetable processes which may otherwise promote this disease.
Objective: To review a variety of studies utilizing rodent models of endometriosis to illustrate their utility in examining mechanisms associated with development and progression
of this disease.
Results: Use of rodent models of endometriosis has provided a much broader understanding of the risk factors for the initial development of endometriosis, the cellular pathology of the disease and the identification of potential therapeutic targets.
Conclusion: Although
there are limitations with any animal model, the variety of experimental endometriosis models that have been developed has enabled investigation into numerous aspects of this disease. Thanks to these models, our understanding of the early processes of disease development, the role of steroid
responsiveness, inflammatory processes and the peritoneal environment has been advanced. More recent models have begun to shed light on how epigenetic alterations contribute to the molecular basis of this disease as well as the multiple comorbidities which plague many patients. Continued developments
of animal models which aid in unraveling the mechanisms of endometriosis development provide the best opportunity to identify therapeutic strategies to prevent or regress this enigmatic disease.
UR - https://www.ingentaconnect.com/content/ben/cwhr/2018/00000014/00000002/art00010
M3 - doi:10.2174/1573404813666170921162041
UR - https://doi.org/10.2174/1573404813666170921162041
ER -