Current Topics in Medicinal Chemistry

Graphical Abstracts
pp. i-iii(3)

Editorial: (Thematic Issue: Medicinal Chemistry of Farnesoid X Receptor (FXR) Modulators: The-State-of-the-Art)
pp. 2127-2128(2)
Author: Marinozzi, Maura

Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands
pp. 2129-2142(14)
Authors: Carotti, Andrea; Marinozzi, Maura; Custodi, Chiara; Cerra, Bruno; Pellicciari, Roberto; Gioiello, Antimo; Macchiarulo, Antonio

Knocking on FXR´s Door: The "Hammerhead"-Structure Series of FXR Agonists – Amphiphilic Isoxazoles with Potent In Vitro and In Vivo Activities
pp. 2143-2158(16)
Authors: Gege, Christian; Kinzel, Olaf; Steeneck, Christoph; Schulz, Andreas; Kremoser, Claus

Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation
pp. 2159-2174(16)
Authors: Gioiello, Antimo; Cerra, Bruno; Mostarda, Serena; Guercini, Chiara; Pellicciari, Roberto; Macchiarulo, Antonio

Recent Advances in Non-Steroidal FXR Antagonists Development for Therapeutic Applications
pp. 2175-2187(13)
Authors: Huang, Huang; Xu, Yong; Zhu, Jin; Li, Jian

Medicinal Chemistry and Pharmacological Effects of Farnesoid X Receptor (FXR) Antagonists
pp. 2188-2205(18)
Authors: Lamers, Christina; Schubert-Zsilavecz, Manfred; Merk, Daniel