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Improvement of Tumor Localization of Photosensitizers for Photodynamic Therapy and Its Application for Tumor Diagnosis

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Photodynamic therapy (PDT) and photodynamic diagnosis of cancer are widely used in clinical fields. These are performed using photosensitizers. Many metalloporphyrin-related compounds have been developed as photosensitizers for use in PDT, and these tumor localization ability have been improved in recent research. Moreover, the precursor of porphyrin 5-aminolevulinic acid is used in fluorescence diagnosis using its tumor localization ability. In this review, these applications of photosensitizers in cancer therapy and diagnosis are summarized.

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Keywords: Photodynamic therapy; aminolevulinic acid; fluorescence diagnosis; hematoporphyrin derivative; hemoglobin; immunoconjugate; ophthalmic tumors; photodynamic diagnosis; photodynamic treatment; photosensitizer; phthalocyanine; porphyrin 5-aminolevulinic acid; target tissues; tumor marker; tumor tissue occurs

Document Type: Research Article

Publication date: February 1, 2012

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