Current Topics in Medicinal Chemistry

Editorial [Hot topic: Drug Design from the ADME/PK Perspective: Does Chemical Intuition Suffice in Multifaceted Drug Discovery? (Guest Editors: Franco Lombardo & Nigel J. Waters)]
pp. 331-333(3)
Authors: Lombardo, F.; J. Waters, Nigel

Predicting Clearance in Humans from In Vitro Data
pp. 334-339(6)
Author: Scott Obach, R.

Controversies in Allometric Scaling for Predicting Human Drug Clearance: An Historical Problem and Reflections on What Works and What Does Not
pp. 340-350(11)
Authors: Tang, Huadong; Mayersohn, Michael

Drug Design Tools - In Silico, In Vitro and In Vivo ADME/PK Prediction and Interpretation: Is PK in Monkey An Essential Part of a Good Human PK Prediction?
pp. 351-357(7)
Author: A. Hosea, Natilie

In-Silico ADME Models: A General Assessment of their Utility in Drug Discovery Applications
pp. 358-381(24)
Authors: Paul Gleeson, M.; Hersey, Anne; Hannongbua, Supa

Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development
pp. 382-403(22)
Authors: O. Nettleton, David; J. Einolf, Heidi

Pharmacodynamic-Pharmacokinetic Integration as a Guide to Medicinal Chemistry
pp. 404-418(15)
Authors: Gabrielsson, Johan; Fjellstrom, Ola; Ulander, Johan; Rowley, Michael; H. Van Der Graaf, Piet

Strategies and Chemical Design Approaches to Reduce the Potential for Formation of Reactive Metabolic Species
pp. 419-449(31)
Authors: A. Argikar, Upendra; B. Mangold, James; P. Harriman, Shawn

Do We Need to Optimize Plasma Protein and Tissue Binding in Drug Discovery?
pp. 450-466(17)
Authors: Liu, Xingrong; Chen, Cuiping; E.C.A. Hop, Cornelis

Discovery and ADMET: Where Are We Now
pp. 467-481(15)
Author: A. Smith, Dennis