Skip to main content
padlock icon - secure page this page is secure

5-HT1 Receptor Augmentation Strategies as Enhanced Efficacy Therapeutics for Psychiatric Disorders

Buy Article:

$68.00 + tax (Refund Policy)

Since the initial observations linking 5-HT to psychiatric illness, evidence for a role of 5-HT and, in particular, a decreased brain serotonergic function in the pathology of a plethora of related disorders, has grown. However, it is the role of 5-HT in the pathogenesis of anxiety disorders and depression and the mechanism of action of antidepressants which has received the most attention. Thus enhanced serotonergic neurotransmission has become one of the unifying mechanisms of action of modern day antidepressants / anxiolytics such as monoamine oxidase inhibitors, tricyclic antidepressants, and serotonin reuptake inhibitors. Interestingly all of these treatments are associated with a delay to therapeutic efficacy and in some cases treatment resistance, despite immediate enhancements in serotonergic neurotransmission. The postulated reason for this is the need for temporal neuroplastic changes in the control of serotonergic neurotransmission, and more specifically changes in 5-HT1 autoreceptor function. Thus significant research has gone into pharmacologically targeting these 5-HT1 autoreceptors as a means of augmenting the efficacy of current therapeutic mechanisms. Here we will review the rationale behind the various augmentation strategies adopted and the progress made in identifying novel therapeutics for conditions such as depression and anxiety disorders.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: 5-HT1A; 5-HT1B; 5-HT1D; Serotonin (5-HT); add-on; anxiety; autoreceptor; depression; serotonin specific reuptake inhibitor (SSRI); serotonin transporter (SERT)

Document Type: Research Article

Affiliations: Psychiatry CEDD,GlaxoSmithKline, New Frontiers Science Park (North), Harlow, Essex,CM19 5AW, UK.

Publication date: August 1, 2008

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more