@article {Schmidt:2006:1568-0266:377,
title = "Inhibitors and Modulators of - and -Secretase",
journal = "Current Topics in Medicinal Chemistry",
parent_itemid = "infobike://ben/ctmc",
publishercode ="ben",
year = "2006",
volume = "6",
number = "4",
publication date ="2006-02-01T00:00:00",
pages = "377-392",
itemtype = "ARTICLE",
issn = "1568-0266",
url = "https://www.ingentaconnect.com/content/ben/ctmc/2006/00000006/00000004/art00007",
doi = "doi:10.2174/156802606776287027",
keyword = "presenilin, secretase, aspartic protease, Alzheimer's disease, inhibitor",
author = "Schmidt, Boris and Baumann, Stefanie and Braun, Hannes A. and Larbig, Gregor",
abstract = "Most gene mutations associated with Alzheimer's disease point to the metabolism of amyloid precursor protein as potential cause. The - and -secretases are two executioners of amyloid precursor protein processing resulting in amyloid . Significant progress has been made in the selective inhibition of both proteases, regardless of structural information for -secretase. Several peptidic and non-peptidic leads were identified and first drug candidates are in clinical trials. This review focuses on the developments since 2003.",
}