Current Topics in Medicinal Chemistry

Preface [Hot topic: Hit-to-Lead: Driving Forces for the Medicinal Chemist (Guest Editor: Benoit Deprez and Rebecca Deprez-Poulain)]
pp. i-i(1)
Authors: Deprez, Benoit; Deprez-Poulain, Rebecca

Preface [Hot topic: Nicotinic Acetylcholine Receptors: Ligand Design Issues (Guest Editor: Jeffrey D. Schmitt)]
pp. ii-ii(1)
Author: Schmitt, Jeffrey D.

Facts, Figures and Trends in Lead Generation
pp. 569-580(12)
Authors: Deprez-Poulain, Rebecca; Deprez, Benoit

The Design of Screening Libraries Targeted at G-Protein Coupled Receptors
pp. 581-589(9)
Author: Crossley, Roger

Molecular Similarity and Property Similarity
pp. 589-600(12)
Authors: Barbosa, Frederique; Horvath, Dragos

“It's The Chemistry, Stupid !”, or: The Impact of Early Discovery Patent Applications on the Drug Development Process
pp. 601-608(8)
Author: Landolt, Frank

Recent Developments in the Synthesis of Nicotinic Acetylcholine Receptor Ligands
pp. 609-629(21)
Author: Breining, Scott R.

Musings on α4β2 Nicotinic Acetylcholine (nACh) Receptor Pharmacophore Models
pp. 631-644(14)
Authors: Glennon, Richard A.; Dukat, Malgorzata; Liao, Liang

Rational Understanding of Nicotinic Receptors Drug Binding
pp. 645-651(7)
Authors: Grutter, Thomas; Le Novere, Nicolas; Changeux, Jean-Pierre