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In recent years a breakthrough has occurred in our understanding of the molecular pathomechanisms of human diseases whereby most of our diseases are related to intra and intercellular communication disorders. The concept of signal transduction therapy has got into the front line of modern drug research, and a multidisciplinary approach is being used to identify and treat signaling disorders.

The aim of this journal is to publish timely in-depth reviews as well as original papers in the field of signal transduction therapy. Thematic issues will also be published to cover selected areas of signal transduction therapy. Coverage of the field will include genomics, proteomics, medicinal chemistry and the relevant diseases involved in signaling e.g. cancer, neurodegenerative and inflammatory diseases.

Current Signal Transduction Therapy is an essential journal for all involved in drug design and discovery.

Publisher: Bentham Science Publishers

Volume 8, Number 3, December 2013

Articles

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Overview of Mechanisms of Cancer Stem Cell Drug Resistance
pp. 180-192(13)
Authors: Kaminska, Bozena; Weronika Kulesza, Dorota; Ramji, Kavita

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Open Access Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops
pp. 193-202(10)
Authors: von Manstein, Viktoria; Min Yang, Chul; Richter, Diane; Delis, Natalia; Vafaizadeh, Vida; Groner, Bernd

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Renal Cell Carcinoma Cancer Stem Cells as Therapeutic Targets
pp. 203-209(7)
Authors: M. Czarnecka, Anna; Szczylik, Cezary

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Open Access Mammalian Target of Rapamycin Inhibitors Resistance Mechanisms in Clear Cell Renal Cell Carcinoma
pp. 210-218(9)
Authors: Kornakiewicz, Anna; Solarek, Wojciech; F. Bielecka, Zofia; Lian, Fei; Szczylik, Cezary; M. Czarnecka, Anna

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Open Access Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in Clear - Cell Renal Cell Carcinoma (ccRCC)
pp. 219-228(10)
Authors: F. Bielecka, Zofia; M. Czarnecka, Anna; Solarek, Wojciech; Kornakiewicz, Anna; Szczylik, Cezary

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Clear Cell Renal Cell Cancer Tumor-Propagating Cells: Molecular Characteristics
pp. 229-239(11)
Authors: Matak, Damian; Szymanski, Lukasz; Czarnecka, Anna; Bartnik, Ewa; Szczylik, Cezary

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Open Access Metastasis-Initiating Cells in Renal Cancer
pp. 240-246(7)
Authors: I. Khan, Mohammed; M. Czarnecka, Anna; Duchnowska, Renata; Kukwa, Wojciech; Szczylik, Cezary

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Immunotherapy Resistance Mechanisms in Renal Cell Cancer
pp. 247-255(9)
Authors: Kaminska, Katarzyna; Wcislo, Gabriel; M. Czarnecka, Anna; Chouaib, Salem; Szczylik, Cezary

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Glioblastoma Stem-Like Cells – Isolation, Biology and Mechanisms of Chemotherapy Resistance
pp. 256-267(12)
Authors: Anna Ciechomska, Iwona; Kocyk, Marta; Kaminska, Bozena

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Predicting Chemotherapy Sensitivity Profiles for Breast Cancer Cell Lines with and Without Stem Cell-Like Features
pp. 268-273(6)
Authors: Isbilen, Murat; Mert Senses, Kerem; Osmay Gure, Ali

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