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In recent years a breakthrough has occurred in our understanding of the molecular pathomechanisms of human diseases whereby most of our diseases are related to intra and intercellular communication disorders. The concept of signal transduction therapy has got into the front line of modern drug research, and a multidisciplinary approach is being used to identify and treat signaling disorders.

The aim of this journal is to publish timely in-depth reviews as well as original papers in the field of signal transduction therapy. Thematic issues will also be published to cover selected areas of signal transduction therapy. Coverage of the field will include genomics, proteomics, medicinal chemistry and the relevant diseases involved in signaling e.g. cancer, neurodegenerative and inflammatory diseases.

Current Signal Transduction Therapy is an essential journal for all involved in drug design and discovery.

Publisher: Bentham Science Publishers

Volume 4, Number 1, January 2009

Articles

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Leptin Signaling: A Key Pathway in Immune Responses
pp. 22-30(9)
Authors: Procaccini, Claudio; Lourenço, Elaine V.; Matarese, Giuseppe; Cava, Antonio L.

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Sonic Hedgehog Pathway as a Target for Therapy in Angiogenesis-Related Diseases
pp. 31-45(15)
Authors: Porro, Chiara; Soleti, Raffaella; Benameur, Tarek; Maffione, Angela B.; Andriantsitohaina, Ramaroson; Martinez, Maria Carmen

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The Role of Methionine Oxidation/Reduction in the Regulation of Immune Response
pp. 46-50(5)
Authors: Agbas, Abdulbaki; Moskovitz, Jackob

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Extracellular HSP90: An Emerging Target for Cancer Therapy
pp. 51-58(8)
Authors: Sidera, Katerina; Patsavoudi, Evangelia

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The Novel Role for Lyn in Integrin Signaling in Human Disease
pp. 59-65(7)
Authors: Tomkowicz, Brian; Ptasznik, Andrzej

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