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Free Content Beta Cell Regeneration in Adult Mice: Controversy Over the Involvement of Stem Cells

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Islet transplantation is an effective therapy for severe diabetes. Nevertheless, the short supply of donor pancreases constitutes a formidable obstacle to its extensive clinical application. This shortage heightens the need for alternative sources of insulin-producing beta cells. Since mature beta cells have a very slow proliferation rate, which further declines with age, great efforts have been made to identify beta cell progenitors in the adult pancreas. However, the question whether facultative beta cell progenitors indeed exist in the adult pancreas remains largely unresolved. In the current review, we discuss the problems in past studies and review the milestone studies and recent publications.
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Keywords: Beta cell mass; Ngn3; beta cell neogenesis; beta cell regeneration

Document Type: Research Article

Publication date: October 1, 2016

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  • Current Stem Cell Research & Therapy publishes frontier reviews on all aspects of basic research on stem cells and their uses in clinical therapy. The journal's aim is to publish the highest quality review articles in the field. The journal is essential reading for all researchers and clinicians involved in stem cells.
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