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Treatment of Isolated Cartilage Lesions of the Knee

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Articular cartilage defects have poor healing capacity and can lead to osteoarthritis. Treatment strategies for isolated cartilage lesions of the knee are discussed with a special focus on natural history and evidence of the effectiveness of procedures. Many approaches have been undertaken during the last two decades to find treatments for biological repair of the cartilage surface. Surgical techniques include debridement, stimulation by microfracture, mosaicplasty, autologous chondrocyte implantation (ACI) and autologous matrix-induced chondrogenesis (AMIC). Although these treatments are promising and scientifically interesting, there is no evidence for a breakthrough in cartilage repair. The evidence justifies cartilage repair procedures in patients with symptomatic full-thickness lesions and in patients with large defects in the weightbearing surface of the knee joint.

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Keywords: Cartilage repair; autologous cartilage implantation; microfracture; mosaicplasty; osteoarthritis

Document Type: Research Article

Publication date: February 1, 2010

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  • Current Rheumatology Reviews publishes frontier reviews on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field.

    The journal is essential reading for all researchers and clinicians in rheumatology.
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