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Use of Liposomal Drugs in the Treatment of Rheumatoid Arthritis

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Rheumatoid arthritis is an autoimmune disease that results in joint deformity and disability. Conventional nonsteroidal anti-inflammatory drugs (NSAIDs), steroids and disease modifying antirheumatic drugs (DMARD's) are used for its treatment. Unconventional therapies, like enzyme oligodeoxy nucleotides, boron neutron capture therapy & radioisotopes are also being tried. The use of all these drugs is limited by a number of adverse effects. These side effects have been overcome to a large extent by the use of liposomes as delivery systems. This review presents rationale for the use of liposomes for the treatment of arthritis. Systemic as well as intra-articular delivery of liposome encapsulated anti-arthritic drugs is discussed. Success and limitations of this approach are also discussed by taking examples of different drug classes.

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Keywords: Arthritis; DMARDs; NSAIDs; corticosteroids; intra-articular; liposomes

Document Type: Research Article

Publication date: February 1, 2008

More about this publication?
  • Current Rheumatology Reviews publishes frontier reviews on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field.

    The journal is essential reading for all researchers and clinicians in rheumatology.
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