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Free Content Cough and Asthma

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Cough is the most common complaint for which patients seek medical attention. Cough variant asthma (CVA) is a form of asthma, which presents solely with cough. CVA is one of the most common causes of chronic cough. More importantly, 30 to 40% of adult patients with CVA, unless adequately treated, may progress to classic asthma. CVA shares a number of pathophysiological features with classic asthma such as atopy, airway hyper-responsiveness, eosinophilic airway inflammation and various features of airway remodeling. Inhaled corticosteroids remain the most important form of treatment of CVA as they improve cough and reduce the risk of progression to classic asthma most likely through their prevention of airway remodeling and chronic airflow obstruction.

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Keywords: Chronic cough; ELISA method; IgE; Mast cells; Sinobronchial syndrome (SBS); Sputum mucin; aeroallergens; airway hyper-responsiveness; airway inflammation; asthma; atopic cough; beta-agonists; biopsy; bronchial mucosal tissue; bronchoalveolar lavage (BAL); bronchoconstriction; bronchodilator-resistant dry cough; bronchodilators; capsaicin; chronic airflow obstruction; classic asthma (CA); computed tomography (CT); cough variant asthma; cough-predominant asthma; cough-reflux selfperpetuating positive feedback cycle; dyspnea; eosinophilic tracheobronchitis; eosinophils; fibrogenic mediators; goblet cell; goblet cell hyperplasia; histamine; histamine H1 receptor antagonists; hyperplasia; inhaled corticosteroid; leukocytes; leukotriene receptor antagonists; leukotrienes C4, D4 and E4; lung parenchyma; methacholine; neutrophilic inflammation; non-asthmatic eosinophilic bronchitis (NAEB); peak expiratory flow (PEF); productive cough; prostaglandins D2; skin test; sputum eosinophilia; theophyllines; thromboxane synthesis inhibitors; vascular proliferation

Document Type: Research Article

Publication date: February 1, 2011

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  • Current Respiratory Medicine Reviews publishes frontier reviews on all the latest advances on respiratory diseases and its related areas e.g. pharmacology, pathogenesis, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in respiratory medicine.
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