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Clinical Potential of Yi-Gan San (Yokukansan) for the Treatment of Psychiatric Disorders

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Yi-gan san (YGS, yokukan-san in Japanese) was developed in 1555 by Xue Kai as a remedy for restlessness and agitation in children. Prompted by the increasing life expectancy of the Japanese population, geriatricians have begun to use this traditional regimen for behavioral and psychological symptoms of dementia in the elderly. Moreover, we reported that YGS therapy is a well-tolerated and effective remedy that improves the symptoms of borderline personality disorder and neuroleptics induced tardive dyskinesia. In a pilot investigation, we administered YGS as an open-label adjunct to antipsychotic medication to patients with treatment-resistant schizophrenia. The present review summarizes the available data supporting the clinical testing of YGS for psychiatric disorders. In addition, we extend our discussion to the potential applications of YGS for combining this treatment with cellular and molecular therapy.





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Document Type: Research Article

Publication date: 01 November 2009

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  • Current Psychiatry Reviews publishes frontier reviews on all the latest advances on clinical psychiatry and its related areas e.g. pharmacology, epidemiology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians, psychiatrists and researchers in psychiatry.
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