Identification of novel small molecule inhibitors against the NS3/4A protease of hepatitis C virus genotype 4a
Methods: The inhibitory efficacy of four computer-designed chemically-synthesized compounds was evaluated against in vitro-expressed NS3/4A protease from HCV genotype 4a, the most prevalent genotype in Egypt, using a fluorescence-based enzymatic assay.
Results: We successfully identified two non-macrocyclic small molecules, BE113 (7a) and BE114 (7b), which exhibited inhibitory activity against HCV NS3/4A protease from HCV genotype 4a.
Conclusion: The two compounds presented in this study may be promising inhibitors against NS3/4A protease of HCV genotype 4a and could be novel lead compounds for developing new therapeutics for the treatment of chronic HCV infection.
Document Type: Research Article
Publication date: October 1, 2018
This article was made available online on January 8, 2019 as a Fast Track article with title: "Identification of Novel Small Molecule Inhibitors Against the NS3/4A Protease of Hepatitis C Virus Genotype 4a".
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