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Anti-aging and Anti-aggregation Properties of Polyphenolic Compounds in C. elegans

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Polyphenols constitute a group of compounds that have been highly investigated for their beneficial effects against various pathologic and non-pathologic conditions and diseases. Among their multi-faceted properties, their anti-oxidant potential nominates them as ideal protective candidates for conditions characterized by elevated levels of oxidative stress, including aging and age-related diseases. The nematode Caenorhabditis elegans is a multicellular model organism that is highly exploited in studies related to aging and age-associated pathologies. In this review, we will summarize studies where polyphenolic compounds have been tested for their anti-aging potential and their protective role against the progression of age-related diseases using C. elegans as their main model.
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Keywords: Aging; C. elegans; age-related diseases; aggregation; longevity; polyphenols; senescence; stress resistance

Document Type: Review Article

Publication date: May 1, 2018

This article was made available online on May 24, 2018 as a Fast Track article with title: "Anti-aging and Anti-aggregation Properties of Polyphenolic Compounds in C. elegans".

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    Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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