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Home / Current Pharmaceutical Design, Volume 20, Number 11
Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Publisher: Bentham Science Publishers

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Volume 20, Number 11, 2014

Articles

Free Content Editorial (Thematic Issue: Epigenetic Regulation and Human Diseases)
pp. 1595-1597(3)
Author: Jiang, Shi-Wen

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The “Methyl-CpG Binding Domain Protein 2” Plays a Repressive Role in Relation to the Promoter CpG Content in the Normal Human Cell Line MRC5
pp. 1598-1603(6)
Authors: Perriaud, Laury; Lachuer, Joel; Dante, Robert

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HDAC Inhibitor Sodium Butyrate Augments the MEF2C Enhancement of Nampt Expression under Hypoxia
pp. 1604-1613(10)
Authors: Yan, Shao-Fei; You, Hong-Jie; Xing, Tian-Yu; Zhang, Chen-Guang; Ding, Wei

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Sirtuins: Nodes Connecting Aging, Metabolism and Tumorigenesis
pp. 1614-1624(11)
Authors: Yao, Yisha; Yang, Yang; Zhu, Wei-Guo

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DNA Demethylation: Where Genetics Meets Epigenetics
pp. 1625-1631(7)
Authors: Zhang, Xiaofei; Fu, Rongguo; Yu, Jie; Wu, Xiaosheng

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Association between MTHFR Gene Polymorphism and the Risk of Ovarian Cancer: A Meta-analysis of the Literature
pp. 1632-1638(7)
Authors: Pu, Danhua; Jiang, Shi-Wen; Wu, Jie

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Folate Deficiency and Aberrant Expression of DNA Methyltransferase 1 were Associated with Cervical Cancerization
pp. 1639-1646(8)
Authors: Jin-tao, Wang; Ling, Ding; Shi-Wen, Jiang; Junxia, Hao; Wei-min, Zhao; Qin, Zhou; Zuo-kai, Yang; Li, Zhang

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Transcription Factor WT1 and Promoter CpG Hypomethylation Coactivate HOXA10 Expression in Ovarian Cancer
pp. 1647-1654(8)
Authors: Jiang, Yi; Chu, Yongli; Tang, Weiwei; Wan, Yicong; Zhang, Lin; Cheng, Wenjun

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Utility of MLH1 Methylation Analysis in the Clinical Evaluation of Lynch Syndrome in Women with Endometrial Cancer
pp. 1655-1663(9)
Authors: S. Bruegl, Amanda; Djordjevic, Bojana; L. Urbauer, Diana; N. Westin, Shannon; T. Soliman, Pamela; H. Lu, Karen; Luthra, Rajyalakshmi; R. Broaddus, Russell

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Development of an Intracellular, DNA Methyltransferase-Specific, and Gene-Specific Assay for Studying Dynamic DNA Methylation
pp. 1664-1673(10)
Authors: Gonzalez-Bosquet, Jesus; Chu, Yongli; Bin Chen, Hai; C. Dowdy, Sean; C. Podratz, Karl; Li, Jinping; Jiang, Shi-Wen

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Driven Hematopoietic Differentiation of Embryonic Stem Cells: Epigenetic Perspectives
pp. 1674-1686(13)
Authors: Tesarova, Lenka; Stejskal, Stanislav; Koutna, Irena

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Histone Modifications, Stem Cells and Prostate Cancer
pp. 1687-1697(11)
Authors: Crea, Francesco; Clermont, Pier-Luc; Mai, Antonello; D. Helgason, Cheryl

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Epigenetic Regulation of EMT: The Snail Story
pp. 1698-1705(8)
Authors: Lin, Yiwei; Dong, Chenfang; P. Zhou, Binhua

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Interplay between Epigenetics & Cancer Metabolism
pp. 1706-1714(9)
Authors: Gupta, Vibhor; Gopinath, P.; Askandar Iqbal, Mohd; Mazurek, Sybille; E. Wellen, Kathryn; N. K. Bamezai, Rameshwar

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Epigenetic Mechanism Involved in the HBV/HCV-Related Hepatocellular Carcinoma Tumorigenesis
pp. 1715-1725(11)
Authors: Rongrui, Liang; Na, Huang; Zongfang, Li; Fanpu, Ji; Shiwen, Jiang

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DNA Methylation, An Epigenetic Mode of Gene Expression Regulation in Reproductive Science
pp. 1726-1750(25)
Authors: Calicchio, Rosamaria; Doridot, Ludivine; Miralles, Francisco; Mehats, Celine; Vaiman, Daniel

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Human Imprinting Anomalies in Fetal and Childhood Growth Disorders: Clinical Implications and Molecular Mechanisms
pp. 1751-1763(13)
Authors: Azzi, Salah; Brioude, Frederic; Le Bouc, Yves; Netchine, Irene

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Epigenetic Inheritance of Paternally Expressed Imprinted Genes in the Testes of ICSI Mice
pp. 1764-1771(8)
Authors: Xu, Xiang-Rong; Fu, Rong-guo; Wang, Li-Ya; Wang, Ning; Zhang, Fan; Le, Fang; Li, Lei; Li, Le-Jun; Liu, Xiao-Zhen; Zheng, Ying-Ming; Lou, Hang-Ying; Jiang, Shi-Wen; Zhu, Xiao-Ming; Zhu, Yi-Min; Huang, He-Feng; Jin, Fan

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Expression of Histone Acetyltransferase GCN5 and Histone Deacetylase 1 in the Cultured Mouse Preimplantation Embryos
pp. 1772-1777(6)
Authors: Liu, Xiaozhen; Zhao, Dongmei; Zheng, Yingming; Wang, Liya; Qian, Yuli; Xu, Chenming; Huang, Hefeng; Lisa Hwa, Yi; Jin, Fan

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Evidence for Epigenetic Alterations in Turner Syndrome Opens up Feasibility of New Pharmaceutical Interventions
pp. 1778-1785(8)
Authors: N. Rajpathak, Shriram; D. Deobagkar, Deepti

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Hypomethylation and Activation of Syncytin-1 Gene in Endometriotic Tissue
pp. 1786-1795(10)
Authors: Zhou, Hongyuan; Li, Jinping; C. Podratz, Karl; Tipton, Tracy; Marzolf, Susan; Bin Chen, Hai; Jiang, Shi-Wen

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Decreased Expression and Altered Methylation of Syncytin-1 Gene in Human Placentas Associated with Preeclampsia
pp. 1796-1802(7)
Authors: Zhuang, Xue-Wei; Li, Jinping; C. Brost, Brian; Xia, Xi-Yan; Bin Chen, Hai; Wang, Chuan-Xin; Jiang, Shi-Wen

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Anti-Tumoral Effect of the Non-Nucleoside DNMT Inhibitor RG108 in Human Prostate Cancer Cells
pp. 1803-1811(9)
Authors: Graca, Ines; J. Sousa, Elsa; Baptista, Tiago; Almeida, Mafalda; Ramalho-Carvalho, Joao; Palmeira, Carlos; Henrique, Rui; Jeronimo, Carmen

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De Novo DNMTs and DNA Methylation: Novel Insights into Disease Pathogenesis and Therapy from Epigenomics
pp. 1812-1818(7)
Authors: Leppert, Sylwia; R. Matarazzo, Maria

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Pharmacoepigenomics: An Interplay of Epigenetic Modulation of Drug Response and Modulation of the Epigenome by Drugs
pp. 1819-1830(12)
Authors: Mendiratta, Shweta; Jain, Shruti; Maini, Jayant; Brahmachari, Vani

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Novel Therapeutic Targets in Neuropsychiatric Disorders: The Neuroepigenome
pp. 1831-1839(9)
Authors: Tremolizzo, Lucio; Rodriguez-Menendez, Virginia; Conti, Elisa; Paola Zoia, Chiara; Cavaletti, Guido; Ferrarese, Carlo

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Epigenetic Drugs in Cognitive Disorders
pp. 1840-1846(7)
Author: Peedicayil, Jacob

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HDAC as a Therapeutic Target for Treatment of Endometrial Cancers
pp. 1847-1856(10)
Authors: Ren, Juan; Zhang, Jia; Cai, Hui; Li, Yi; Zhang, Yuelang; Zhang, Xiaozhi; Zhao, Dongli; Li, Zongfang; Ma, Hongbing; Wang, Jiansheng; Gao, Yan-e; Xiao, Lisha; Liu, Rui; Qian, Jiansheng; Liu, Yan; Wei, Hongxia; Li, Jinping

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Epigenetic Interventions Increase the Radiation Sensitivity of Cancer Cells
pp. 1857-1865(9)
Authors: Ren, Juan; Chu, Yongli; Ma, Hongbing; Zhang, Yuelang; Zhang, Xiaozhi; Zhao, Dongli; Li, Zongfang; Wang, Jiansheng; Gao, Yan-e; Xiao, Lisha; Liu, Rui; Qian, Jiansheng; Liu, Yan; Wei, Hongxia; Jiang, Shiwen

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Comprehensive Analysis for Histone Acetylation of Human Colon Cancer Cells Treated with a novel HDAC Inhibitor
pp. 1866-1873(8)
Authors: Zhao, Yunlong; Fang, Xiuli; Wang, Ye; Zhang, Junmei; Jiang, Sheng; Liu, Zhe; Ma, Zhenyi; Xu, Liyan; Li, Enmin; Zhang, Kai

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Epigenetic Modification Restores Functional PR Expression in Endometrial Cancer Cells
pp. 1874-1880(7)
Authors: Yang, Shujie; Xiao, Xue; Jia, Yichen; Liu, Xiaoyue; Zhang, Yuping; Wang, Xinjun; J. Winters, Christopher; J. Devor, Eric; Meng, Xiangbing; W. Thiel, Kristina; K. Leslie, Kimberly

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Cytostatic and Apoptotic Effects of DNMT and HDAC Inhibitors in Endometrial Cancer Cells
pp. 1881-1887(7)
Authors: Xu, Shaohua; Ren, Juan; Bin Chen, Hai; Wang, Yanlin; Liu, Qingyou; Zhang, Run; Jiang, Shi-Wen; Li, Jinping

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The Biphasic Expression Pattern of miR-200a and E-cadherin in Epithelial Ovarian Cancer and its Correlation with Clinicopathological Features
pp. 1888-1895(8)
Authors: Xu, Shaohua; Xu, Peizhen; Wu, Wei; Ou, Yangjun; Xu, Juan; Zhang, Guanghua; Li, Jinping; Xu, Guofeng

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A Family of Pleiotropically Acting MicroRNAs in Cancer Progression, miR-200: Potential Cancer Therapeutic Targets
pp. 1896-1903(8)
Authors: Zhang, Hai-Feng; Xu, Li-Yan; Li, En-Min

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Relations between GPR4 Expression, Microvascular Density (MVD) and Clinical Pathological Characteristics of Patients with Epithelial Ovarian Carcinoma (EOC)
pp. 1904-1916(13)
Authors: Ren, Juan; Jin, Wen; Gao, Yan-e; Zhang, Yuelang; Zhang, Xiaozhi; Zhao, Dongli; Ma, Hongbing; Li, Zongfang; Wang, Jiansheng; Xiao, Lisha; Liu, Rui; Chen, Yuanyuan; Qian, Jiansheng; Niu, liying; Wei, Hongxia; Liu, Yan

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Oxidative Stress Upregulates PDCD4 Expression in Patients with Gastric Cancer via miR-21
pp. 1917-1923(7)
Authors: Tu, Honglei; Sun, Haibing; Lin, Yan; Ding, Jie; Nan, Kejun; Li, Zongfang; Shen, Qiang; Wei, Yongchang

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