Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Diamanti-Kandarakis, Evanthia
AU - Christakou, Charikleia
AU - Marinakis, Evangelos
TI - Phenotypes and Enviromental Factors: Their Influence in PCOS
JO - Current Pharmaceutical Design
PY - 2012-01-01T00:00:00///
VL - 18
IS - 3
SP - 270
EP - 282
KW - hyperandrogenism
KW - environment
KW - anovulation
KW - AGEs
KW - PCOS
KW - diet
KW - endocrine disruptors
KW - ovulatory dysfunction
KW - phenotypes
KW - adipose tissue
N2 - Polycystic ovary syndrome (PCOS) is a complex syndrome of unclear etiopathogenesis characterized by heterogeneity in phenotypic manifestations. The clinical phenotype of PCOS includes reproductive and hormonal aberrations, namely anovulation and hyperandrogenism, which coexist with
metabolic disturbances. Reflecting the crosstalk between the reproductive system and metabolic tissues, obesity not only deteriorates the metabolic profile but also aggravates ovulatory dysfunction and hyperandrogenism.
Although the pathogenesis of PCOS remains unclear, the syndrome appears
to involve environmental and genetic components. Starting from early life and extending throughout lifecycle, environmental insults may affect susceptible women who finally demonstrate the clinical phenotype of PCOS.
Diet emerges as the major environmental determinant of PCOS. Overnutrition
leading to obesity is widely recognized to have an aggravating impact, while another detrimental dietary factor may be the high content of food in advanced glycated end products (AGEs). Environmental exposure to industrial products, particularly Bisphenol A (BPA), may also exacerbate the clinical
course of PCOS. AGEs and BPA may act as endocrine disruptors in the pathogenesis of the syndrome.
PCOS appears to mirror the harmful influence of the modern environment on the reproductive and metabolic balance of inherently predisposed individuals.
UR - https://www.ingentaconnect.com/content/ben/cpd/2012/00000018/00000003/art00006
M3 - doi:10.2174/138161212799040457
UR - https://doi.org/10.2174/138161212799040457
ER -