@article {Jirillo:2010:1381-6128:870,
title = "Ability of Goat Milk to Modulate Healthy Human Peripheral Blood Lymphomonocyte and Polymorphonuclear Cell Function: In vitro Effects and Clinical Implications",
journal = "Current Pharmaceutical Design",
parent_itemid = "infobike://ben/cpd",
publishercode ="ben",
year = "2010",
volume = "16",
number = "7",
publication date ="2010-03-01T00:00:00",
pages = "870-876",
itemtype = "ARTICLE",
issn = "1381-6128",
url = "https://www.ingentaconnect.com/content/ben/cpd/2010/00000016/00000007/art00017",
doi = "doi:10.2174/138161210790883534",
keyword = "Interleukins, milk, peripheral blood mononuclear cells, nitric oxide",
author = "Jirillo, F. and Martemucci, G. and D'Alessandro, A. G. and Panaro, M. A. and Cianciulli, A. and Superbo, M. and Jirillo, E. and Magrone, T.",
abstract = "The in vitro effects of goat's milk from different sources (Jonica, Saanen, and Priska breeds plus a commercial preparation) on healthy human peripheral blood mononuclear cells (PBMCs) were evaluated in terms of nitric oxide (NO) and cytokine release. According to the incubation time (24 h or 48 h) used all milks could induce release of NO from monocytes. In this context, however, in the presence of a commercial milk preparation inhibition of lypopolysaccharide (LPS)-induce NO generation was evident. Also polymorphonuclear cells stimulated with the various milks released detectable amounts of NO. In the case of Priska milk inhibition of LPS-mediated NO generation was observed. Despite a broad array of cytokines tested [Interleukin (IL)-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, Tumor Necrosis Factor (TNF)-, Transforming Growth Factor- and Granulocyte Colony Stimulating Factor] only IL-10, TNF-, and IL-6 were released by PBMCs upon stimulation with various milks. Taken together, these data indicate that goat's milk for its capacity to produce NO may exert a cardioprotective and anti-atherogenic effect in consumers. Moreover, induction of proinflammatory (TNF- and IL-6) and anti-inflammatory (IL-10) cytokines suggests the ability of this milk to maintain immune homeostasis in the immunocompromised host (e.g., aged people).",
}