@article {Yang:2017:1389-2010:849,
title = "Antioxidant Activity, -glucosidase Inhibitory Activity and Chemoprotective Properties of Rhododendron brachycarpum Leaves Extracts",
journal = "Current Pharmaceutical Biotechnology",
parent_itemid = "infobike://ben/cpb",
publishercode ="ben",
year = "2017",
volume = "18",
number = "10",
publication date ="2017-08-01T00:00:00",
pages = "849-854",
itemtype = "ARTICLE",
issn = "1389-2010",
url = "https://www.ingentaconnect.com/content/ben/cpb/2017/00000018/00000010/art00013",
doi = "doi:10.2174/1389201019666171204113747",
keyword = "Antimicrobial activity, antioxidant, a-Glucosidase, chemoprotective, DNA cleavage, Rhododendron brachycarpum",
author = "Yang, Jinfeng and Kim, Myeong O. and Kwon, Yong Soo and Kim, Myong Jo",
abstract = "Background: Rhododendron brachycarpum (RB) is a genus of flowering plants generally used for traditional medicine in Korea to treat hypertension, neuralgia, and sterility. Previous studies have shown that RB extract alleviate inflammation and antimicrobial activity. Objective:
In this study, the effects of RB and its different fractions (n-hexane, ethyl-acetate and n-butanol) on antioxidant activity, DNA damage prevention and the activity of -glucosidase were studied. Results: The antioxidant ability of RB was investigated in vitro, including that
of DPPH-radical and reducing power. As expected, scavenging effect against DPPH-radical of ethyl acetate fraction (IC50 = 17.7 \textpm 0.5 g/ml) of RB had the highest DPPH radical scavenging activity, and it was superior to the positive control, butylated hydroxytoluene (BHT) (IC50 =
80.8 \textpm 1.5 g/ml). And the reducing power of RB was 3.18 at 1.0 mg/ml. Meanwhile, the -glucosidase inhibitory activity and prevention of oxidation stress-induced DNA damage were also highest in the ethyl acetate fraction. Pretreatment of pancreatic -cells from Syrian
golden hamster (HIT-TI5) with the ethyl acetate fraction at concentrations of 300 g/ml significantly protected the cells from high glucose-induced cell death. Conclusion: Our results indicate that ethyl acetate fraction of RB leaves extract has strong antioxidant, -glucosidase,
and prevention of DNA damage activities, and furthermore, ethyl acetate fraction significantly protected the cells from high glucose-induced cell death.",
}