Skip to main content
padlock icon - secure page this page is secure

Proteomic Analysis of Phosphorylation in the Brain

Buy Article:

$68.00 + tax (Refund Policy)

Protein phosphorylation is a key post-translational modification that controls intracellular signalling in virtually all cell types. In the nervous system, it contributes to the regulation of neuronal signalling, and processes underlying synaptic plasticity and cognitive functions. Despite its importance for brain functions, knowledge about the brain phosphoproteome has remained incomplete. A pre-requisite for gaining such knowledge and better understanding the molecular and biochemical bases of brain functions is to carry out quantitative analyses of protein phosphorylation and its dynamics. Such analyses require high-throughput methodologies, which in recent years, have greatly benefited from advances in proteomics and genomics, and have been combined with computational modelling. Current phosphoproteomic workflows have reached a level of maturity that permits their combination with molecular approaches, and their application to the study of higher-order brain functions and cognitive processes. Neuroproteomics has thus emerged as an important novel sub-field of neurosciences. This review focuses on the proteomic methodologies currently used to study phosphorylation in the brain, and recent examples of their application.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Brain; isobaric tagging; nerve cell/neuron; neuroproteomics; phosphopeptide enrichment; phosphoproteomics; phosphorylation; quantitative mass spectrometry; stable isotope labelling

Document Type: Research Article

Publication date: October 1, 2012

More about this publication?
  • Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more