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Proteins as Networks: A Mesoscopic Approach Using Haemoglobin Molecule as Case Study

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Protein structures allow for a straightforward representation in terms of graph theory being the nodes the aminoacid residues and the edges the scoring of a spatial contact between the node pairs. Such a representation allows for a direct use in the realm of protein science of the vast repertoire of graph invariants developed in the analysis of complex networks. In this work we give a general overview of the protein as networks paradigm with a special emphasis on haemoglobin where the most important features of protein systems like allostery, protein-protein contacts and differential effect of mutations were demonstrated to be amenable to a graph theory oriented translation.

Document Type: Research Article

Publication date: December 1, 2009

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  • Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.
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