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Catalytic Enantioselective Constructions of Trifluoromethylated Chiral Stereogenic Centers via the Conjugate Addition to CF3-Alkenes: Overview of Current Progress

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Synthetic methods for the enantioselective constructions of trifluoromethylated stereogenic centers are described. In particular, this review focuses on recent examples of catalytic enantioselective transformations with trifluoromethyl alkenes. These reactions efficiently synthesized chiral compounds with trifluoromethylated stereogenic centers.

Keywords: Diels-Alder reaction; Trifluoromethyl group; chiral catalyst; conjugate addition; enantioselective synthesis; trifluoromethyl alkenes

Document Type: Research Article

Publication date: August 1, 2015

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