Skip to main content
padlock icon - secure page this page is secure

Bifunctional Organocatalysts in the Asymmetric Michael Additions of Carbonylic Compounds to Nitroalkenes

Buy Article:

$68.00 + tax (Refund Policy)

In the past decade, the organocatalytic asymmetric Michael addition has emerged as one of the most important carbon-carbon bond forming reactions in organic chemistry. As an example, the conjugated addition of ketones to nitroolefins has received extensive attention, since the resulting nitroalkanes are versatile intermediates in which the nitro group can be transformed into various useful functional groups. Furthermore, the reaction has the ability to introduce two vicinal stereogenic centers in a single step. Stimulated by the seminal work of List, Barbas and coworkers, several research groups have focused on the development of novel bifunctional organocatalysts bearing amine and hydrogen donor functionalities.

This review will focus on the development of multifunctional chiral organocatalysts derived from proline, pyrrolidine, cinchona alkaloids, thioureas and sulfonamides in the asymmetric Michael addition to nitroalkenes.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: 4-dimethylaminopiridine; Asymmetric; Bifunctional; Ketones; Michael Additions; Nitroalkenes; Organocatalysts; enantioselectivity; β-amino acid; β-nitrostyrene

Document Type: Research Article

Publication date: October 1, 2012

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more