Skip to main content
padlock icon - secure page this page is secure

Transition Metal Ion Complexes of N-alkylguanines

Buy Article:

$68.00 + tax (Refund Policy)

The family of cisplatin and its analogues contains some of the most powerful anticancer drugs developed to date and, since their discovery, extensive efforts have been devoted to understand their mode of action. 9-Alkylguanines have featured widely in these studies as model nucleobases. This review describes both the synthesis and the chemical, biological and miscellaneous spectroscopic properties of a variety of transition metal ion (Pt, Pd, Ru, Os, Rh, Re, Tc, Zn, Cu, Cd) complexes of N-alkylguanines (mostly 9- alkylguanines) which have been reported in the literature principally within the 2003-2008 period. Special attention has been given to the acid-base properties of these complexes, where coordination to transition metal ions usually leads to significant acidification of the guaninyl N1-H proton, and its consequences

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: CADMIUM(II) COMPLEXES; Guanine; N-alkylguanines; N7 atom; OSMIUM(II); RUTHENIUM(II); RUTHENIUM(III); TECHNETIUM(I) COMPLEXES; acid-base properties; anticancer agents; cisplatin; metallocenes; nucleic acids; spectroscopic properties; transition metal complexe

Document Type: Research Article

Publication date: August 1, 2011

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more