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Peptide Backbone Modifications

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The selective introduction or manipulation of side chains in a peptide represents a severe synthetic challenge. During the last years numerous different approaches towards the targeted modification of small to medium-sized peptides have been developed which should be presented in this review. Focusing on the manipulation of the peptide backbone, procedures concerning selective N-alkylation, C-alkylation and Cequals;O-thionation are described.





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Document Type: Research Article

Publication date: March 1, 2008

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