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Magnetic and Gold-Coated Magnetic Iron Oxide Nanoparticles as Detection Tools: Preparation, Characterization, and Biosensing Applications

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Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Nanomaterials such as magnetic iron oxides and magnetic gold-coated iron oxides nanoparticles exhibit unusual optical, thermal, chemical, and physical properties, due to a combination of high-energy surface atoms compared to bulk solids. Their low toxicity, biocompatibility, and established protocols of synthesis have resulted in a tremendous upsurge of interest, and their applications as special biomolecule carriers via a stable immobilization process show promise as sensitive detection tools. This review provides a comprehensive analysis of new synthetic routes, characterization methodologies, and functionalization protocols of magnetic and gold-coated magnetic iron oxides nanoparticles. Applications of these materials as scaffolds for biosensing and detection are also discussed.

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Keywords: DNA hybridization; Magnetic iron oxide nanoparticles; Nanomaterials; aptamer; biodetection; biosensing; enzymes; functionalization; functionnalization; gold-coated iron oxides nanoparticles; gold-coated magnetite; magnetic nanoparticles; prion; surface coating

Document Type: Research Article

Publication date: August 1, 2011

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  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.
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