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Synthesis, Characterization and Biodegradation of Novel Poly(L-lactide)/Multiwalled Carbon Nanotube Porous Scaffolds for Tissue Engineering Applications

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This paper reports on the synthesis and characterization of novel poly(L-lactide)/multi-walled carbon nanotube (PLLA/MWCNT) porous scaffolds prepared by the freeze-extraction method. The obtained scaffolds showed well-distributed and interconnected porous structures with more than 80% porosity and median pore size around 40 μm distributed within a region between 50 and 150 μm in size. As a result of high interfacial interaction between PLLA and the MWCNTs, the scaffolds exhibited remarkable improvements in mechanical properties such as strength, modulus and elongation. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) showed enhanced thermal stability and compatibility for PLLA/MWCNT scaffolds. The structural properties of the scaffolds were investigated by Fourier-transform infrared spectroscopy (FTIR). In vitro degradation studies of the scaffolds were assessed by immersing the scaffolds in phosphate buffered saline (PBS) for up to 24 weeks. It was found that the incorporation of MWCNTs in PLLA scaffolds decreased the rate of in vitro degradation.

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Keywords: Biodegradable polymers; Biodegradation; Carbon Nanotubes; Fe catalyst; Field Emission Properties; Freeze-extraction method; Low Pressure Chemical Vapor Deposition; Mechanical properties; Multi-walled carbon nanotubes; Nanocomposites; RF sputtering; Radial Breathing Mode; Raman Spectroscopy; Scanning Electron Microscope; Single-walled carbon nanotubes; Swelling degree; Thermal Properties; Weight loss; in vitro degradation; multi-walled carbon nanotubes; poly(L-lactide); porous scaffold; tissue engineering

Document Type: Research Article

Publication date: June 1, 2011

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  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.
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