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Craniofacial Anomalies: From Development to Molecular Pathogenesis

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Advances in developmental biology combined with progress in human genetics are helping us decipher how the craniofacial region develops and how the consequences of misdirected development result in malformation. This review describes the molecular etiology of a number of craniofacial developmental anomalies. The more common craniofacial anomalies cleft lip and palate and craniosynostosis, as well as cleidocranial dysplasia, hemifacial microsomia, holoprosencephaly, enlarged parietal foramina, Treacher Collins syndrome and cherubism are discussed.
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Keywords: Cleft lip and palate; Treacher Collins syndrome; cherubism; cleidocranial dysplasia; craniofacial development; craniosynostosis; hemifacial microsomia; holoprosencephaly; parietal foramina

Document Type: Review Article

Affiliations: Departments of Craniofacial Development and Orthodontics, King's College London, London, UK.

Publication date: November 1, 2005

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  • Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.
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