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DNA Microarrays in Clinical Cancer Research

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The recent sequencing of the human genome, coupled with advances in biotechnology, is enabling the comprehensive molecular “profiling” of human tissues. In particular, DNA microarrays are powerful tools for obtaining global views of human tumor gene expression. Complex information from tumor “expression profiling” studies can, in turn, be used to create novel molecular cancer diagnostics. We discuss the utility of DNA microarray-based tumor profiling in clinical cancer research, highlight some important recent studies, and identify future avenues of research in this evolving field.
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Keywords: cdna; hybridization; microarray-based gene expression; polymerase chain reaction; translocations

Document Type: Review Article

Affiliations: Center for Cancer Research, Massachusetts General Hospital, Building 149, Room 7214, 13th Street, Charlestown, MA 02129, USA.

Publication date: February 1, 2005

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  • Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal will invite guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.
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