@article {Baumann:2002:1566-5240:257,
title = "Regulation of T cell Apoptosis during the Immune Response",
journal = "Current Molecular Medicine",
parent_itemid = "infobike://ben/cmm",
publishercode ="ben",
year = "2002",
volume = "2",
number = "3",
publication date ="2002-05-01T00:00:00",
pages = "257-272",
itemtype = "ARTICLE",
issn = "1566-5240",
url = "https://www.ingentaconnect.com/content/ben/cmm/2002/00000002/00000003/art00003",
doi = "doi:10.2174/1566524024605671",
keyword = "T cell Apoptosis, CD95 SIGNALING PATHWAY, DEATH RECEPTORS, THYMOCYTE SELECTION, FLICE inhibitory protein, Immune Response, Death domain",
author = "Baumann, S. and Krueger, A. and Kirchhoff, S. and Krammer, P.H.",
abstract = "Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire selection during T cell maturation and homeostasis of the immune system. It also plays a key role in elimination of autoreactive lymphocytes. Resting mature T cells are activated by antigen to elicit an appropriate immune response. In contrast, preactivated T cells undergo activation-induced cell death (AICD) in response to TCR triggering alone. Thus, death by apoptosis is essential for function, growth and differentiation of T-lymphocytes. This review focuses on apoptosis mechanisms involved in T cell development and during the course of an immune response.",
}