The Design and Application of Nanomaterials as Drug Carriers in Cancer Treatment
The development of new medical cancer treatment technologies is of great significance in
reducing cancer mortality. Traditional clinical cancer therapy has a short drug action time, difficulty
in accurately targeting tumour tissues and high levels of toxicity in normal tissues. With the development
of nanotechnology, nanomaterials have been used as drug carriers to specifically target cancer
cells and release drugs into the tumour environment. This technique has become an important
research hotspot in cancer treatment. There are several advantages of using nanomaterials for cancer
treatment that improve the efficacy of drug delivery, including increased drug concentrations in the
targeted tumour area, reduced toxicity in normal tissues and controlled drug release. In this work,
we describe the latest research development on the use of nanomaterials for drug delivery in cancer
treatment and explore related mechanistic pathways. In addition, the methods used to control drug
release into the targeted area using nanocarriers are reviewed in detail. Overall, we present current
achievements using nanomaterials and nanotechnologies in cancer treatment, followed by current
challenges and future prospects.
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cancer cells and tissues;
Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Chongqing Key Laboratory of Non-linear Circuit and Intelligent Information Processing, College of Electronic and Information Engineering, Southwest University, Chongqing 400715, China.
Key Laboratory of Medical Electrophysiology, Ministry of Education, Department of Cardiology, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Appeared or available online: September 13, 2019