Current Medicinal Chemistry

Meet the Editorial Board:
pp. 405-405(1)
Author: Ferro, Vito

Editorial (Thematic Issue: Bioactivation of Drugs: Enzymes, Reactive Metabolites and Adverse Reactions)
pp. 406-407(2)
Author: Orhan, Hilmi

Extrahepatic Targets and Cellular Reactivity of Drug Metabolites
pp. 408-437(30)
Author: Orhan, Hilmi

Should the Incorporation of Structural Alerts be Restricted in Drug Design? An Analysis of Structure-Toxicity Trends with Aniline-Based Drugs
pp. 438-464(27)
Author: Kalgutkar, A.S.

Gauging Reactive Metabolites in Drug-Induced Toxicity
pp. 465-489(25)
Authors: R. Eno, Marsha; D. Cameron, Michael

Melatonin, its Metabolites and its Synthetic Analogs as Multi-Faceted Compounds: Antioxidant, Prooxidant and Inhibitor of Bioactivation Reactions
pp. 490-499(10)
Authors: Gurer-Orhan, Hande; Suzen, Sibel

Biotransformation of Endocrine Disrupting Compounds by Selected Phase I and Phase II Enzymes – Formation of Estrogenic and Chemically Reactive Metabolites by Cytochromes P450 and Sulfotransferases
pp. 500-527(28)
Authors: Reinen, J.; Vermeulen, N.P.E.

Idiosyncratic Drug Hepatotoxicity: Strategy for Prevention and Proposed Mechanism
pp. 528-537(10)
Author: Ikeda, Toshihiko

Reactive Metabolites in Early Drug Development: Predictive In vitro Tools
pp. 538-550(13)
Authors: Pelkonen, Olavi; Pasanen, Markku; Tolonen, Ari; Koskinen, Mikko; Hakkola, Jukka; Abass, Khaled; Laine, Jaana; Hakkinen, Merja; Juvonen, Risto; Auriola, Seppo; Storvik, Markus; Huuskonen, Pasi; Rousu, Timo; Rahikkala, Maiju