Nearly 200 X-Ray Crystal Structures of Transthyretin: What Do They Tell Us About This Protein and the Design of Drugs for TTR Amyloidoses?
Keywords: Amyloidosis; amyloidogenicity; cardiomyopathy; crystal structure; inhibitor complex; native state kinetic stabilization; protein misfolding; retinol binding protein; thyroxine (T4); transthyretin (TTR)
Document Type: Research Article
Affiliations: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, USA.
Publication date: 01 May 2012
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