Scaffold Vascularization: A Challenge for Three-Dimensional Tissue Engineering
This paper reviews some scaffold materials used in tissue engineering and the effect of their properties on the vascularization process. Also, it specifically addresses the pivotal role of biomaterials vascularization in tissue engineering applications, along with the effect of angiogenic factors and adhesive molecules on angiogenesis. Assays and markers of angiogenesis are also outlined. One section highlights the need for bioreactor cultures and mechanical conditioning in controlling endothelial cell responses. Finally, we conclude with a brief section on the effects of oxygen concentration and hypoxia over microvessel formation.
Keywords: Collagens; Expanded polytetrafluoroethylene; FAK; GAG; HSPG; Heparan sulphate proteoglycans; PTFE; Polyanhydrides; Polysaccharides; VEGF; VEGFA; VEGFB; VEGFC; VEGFD; Vascularization; adhesion molecules; angiogenesis; angiogenesis markers; bFGF; biomaterials; bioreactor; ePTFE; fibroblast growth factor; focal adhesion kinases; glycosaminoglycans; growth factors; hypoxia; mechanical conditioning; microvessels; multiplexins; placental-like growth factor; polytetrafluoroethylene; porous scaffolds; vascular endothelial growth factor
Document Type: Research Article
Publication date: January 1, 2010
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