@article {Ruiz-Azuara:2010:0929-8673:3606,
title = "Copper Compounds in Cancer Chemotherapy",
journal = "Current Medicinal Chemistry",
parent_itemid = "infobike://ben/cmc",
publishercode ="ben",
year = "2010",
volume = "17",
number = "31",
publication date ="2010-11-01T00:00:00",
pages = "3606-3615",
itemtype = "ARTICLE",
issn = "0929-8673",
url = "https://www.ingentaconnect.com/content/ben/cmc/2010/00000017/00000031/art00002",
doi = "doi:10.2174/092986710793213751",
keyword = "cytostatic, imidazole, Wilson disease (WD), antitumor agents, Cancer Chemotherapy, Oxalilplatino, Leukemia L1210, hematological effects, L-amino acidate, benzimidazole, medulloblastoma, genotoxic, Melanoma B16, tumor cell growth, metal-ligand combination, Menkes disease (MD), medicinal inorganic chemistry, thiosemicarbazone complexes, murine glioma, ascorbate oxidase, cisplatin (CDDP), diimine ligand, Casiopeína III-ia, copper Casiopeinas, Lobaplatino, copper-based antitumor agents, Isatin-Schiff base copper (II), DNA targeting, copper-biological molecules, antineoplastic drug, Pt clinical drugs, low hydrosolubility, therapeutic potential, Copper compounds, glutathione depletion, organic based drugs, tyrosinase, bipyridine complexes, phenanthroline, Nedaplatino, Structure-Activity Relationships, Cu (II) thiosemicarbazidecomplexes, mixed-ligand complexes, Casiopeína II-gly, platinum-based drugs, Carboplatino, recognition of target sites, antitumor activi-ties, cisplatin therapy, cell proliferation, phenanthroline basicity, antiproliferative activity, Casiopeínas®, phenanthrolines, cardiovascular toxicity, Cytotoxicity, geometries, hemolytic anemia, genotoxic activity, drugs",
author = "Ruiz-Azuara, L. and E. Bravo-Gomez, M.",
abstract = "Transitional metals have a large variety of coordination numbers and geometries, accessible redox states in physiological conditions and a wide range of thermodynamic and reactivity properties which can be successfully tuned by selection of suitable ligands. These characteristics can be used to develop new drugs with numerous advantages over the organic based drugs. Historically, research in this field has focus on platinum and DNA targeting; however, anticancer drug research may be expanded to include alternative metal compounds with different mode of action resulting in markedly different cytotoxic response profiles. Copper complexes with selected ligands are being extensively studied as agents for the treatment of cancer. Current research on copper compounds as antitumoral compounds is being reviewed in this chapter particularly focused on the family of copper Casiopeinas. ",
}