Skip to main content
padlock icon - secure page this page is secure

Copper Compounds in Cancer Chemotherapy

Buy Article:

$68.00 + tax (Refund Policy)

Transitional metals have a large variety of coordination numbers and geometries, accessible redox states in physiological conditions and a wide range of thermodynamic and reactivity properties which can be successfully tuned by selection of suitable ligands. These characteristics can be used to develop new drugs with numerous advantages over the organic based drugs. Historically, research in this field has focus on platinum and DNA targeting; however, anticancer drug research may be expanded to include alternative metal compounds with different mode of action resulting in markedly different cytotoxic response profiles. Copper complexes with selected ligands are being extensively studied as agents for the treatment of cancer. Current research on copper compounds as antitumoral compounds is being reviewed in this chapter particularly focused on the family of copper Casiopeinas.

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Cancer Chemotherapy; Carboplatino; Casiopeína II-gly; Casiopeína III-ia; Casiopeínas®; Copper compounds; Cu (II) thiosemicarbazidecomplexes; Cytotoxicity; DNA targeting; Isatin-Schiff base copper (II); L-amino acidate; Leukemia L1210; Lobaplatino; Melanoma B16; Menkes disease (MD); Nedaplatino; Oxalilplatino; Pt clinical drugs; Structure-Activity Relationships; Wilson disease (WD); antineoplastic drug; antiproliferative activity; antitumor activi-ties; antitumor agents; ascorbate oxidase; benzimidazole; bipyridine complexes; cardiovascular toxicity; cell proliferation; cisplatin (CDDP); cisplatin therapy; copper Casiopeinas; copper-based antitumor agents; copper-biological molecules; cytostatic; diimine ligand; drugs; genotoxic; genotoxic activity; geometries; glutathione depletion; hematological effects; hemolytic anemia; imidazole; low hydrosolubility; medicinal inorganic chemistry; medulloblastoma; metal-ligand combination; mixed-ligand complexes; murine glioma; organic based drugs; phenanthroline; phenanthroline basicity; phenanthrolines; platinum-based drugs; recognition of target sites; therapeutic potential; thiosemicarbazone complexes; tumor cell growth; tyrosinase

Document Type: Research Article

Publication date: November 1, 2010

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more